Systemic fungicides protect plants by moving through the tissues to combat diseases from within. They’re designed for lawns, ornamentals, roses, and vegetables, offering both curative and preventive protection. This guide highlights five effective options, covering coverage, strength, and application considerations to help you choose the right product for your garden or landscape.
| Product | Brand | Volume | Ideal For |
|---|---|---|---|
| Fertilome (11378) Liquid Systemic Fungicide II | ferti-lome | 32 oz | Roses, flowers, lawns, trees |
| Bonide Infuse Systemic Disease Control (16 oz) | Bonide | 16 oz | Turf and ornamentals |
| Atticus Gravex 20EW Fungicide (16 oz) | Atticus | 16 oz | Lawns, landscapes, greenhouses |
| Quest Reliant Systemic Fungicide 32 oz | VivaGrow | 32 oz | Phytophthora, Pythium, mildews |
| Bonide Infuse Systemic Disease Control (32 oz Ready-to-Spray) | Bonide | 32 oz | Turf and ornamentals |
Fertilome Liquid Systemic Fungicide II

The Fertilome Liquid Systemic Fungicide II is a broad-spectrum control option designed to protect roses, flowers, lawns, and trees from major fungal diseases such as Take All Patch, Brown Patch, Dollar Spot, and Leaf Spot. This 32-ounce liquid concentrate blends with water for convenient application across turf and ornamental plantings. Its systemic action helps protect new growth, reducing repeated infections and improving overall plant health over time. Consider it when you need a versatile solution for mixed landscapes and seasonal disease pressure.
Bonide Infuse Systemic Disease Control (16 oz)

Bonide Infuse Systemic Disease Control Concentrate provides broad-spectrum systemic protection for turf and ornamentals. This 16-ounce bottle is formulated to protect roses, flowers, lawns, trees, and shrubs from rust, blight, powdery mildew, scab, leaf spots, and more. The product emphasizes long-lasting protection and durability against a wide range of diseases, making it suitable for seasonal disease management in both home lawns and garden beds.
Atticus Gravex 20EW Fungicide (16 oz)

Gravex 20 EW Fungicide contains myclobutanil (19.7%), offering strong, lasting control of a broad spectrum of plant fungi. It performs both curative and preventive roles, stopping established infections and preventing new ones. Gravex targets more than 38 fungi, including brown patch, anthracnose, powdery mildew, rust, scab, and leaf spots in turf and ornamentals. This dual-action approach helps maintain healthy growth in lawns and landscape plantings during active disease periods.
Quest Reliant Systemic Fungicide 32 oz

Quest Reliant Systemic Fungicide, a 32-ounce solution, shares its formulation and strength with Agri-Fos and Garden-Phos. It provides broad protection against Phytophthora, Pythium, downy mildews, apple scab, Xanthomonas, Erwinia, root rots, blights, mildews, and more. By activating the plant’s natural defense mechanisms, Reliant helps plants resist invasions by numerous pathogens, supporting healthier growth in diverse garden settings from lawns to ornamentals.
Bonide Infuse Systemic Disease Control (32 oz Ready-to-Spray)

This ready-to-spray version provides broad-spectrum, systemic disease control for turf and ornamentals. It’s designed for quick, uniform application across lawns, flowers, trees, and shrubs, delivering protection against rust, blight, powdery mildew, scab, leaf spots, and more. The 32-ounce bottle expands coverage for larger landscapes and reduces the need for multiple refills during a single treatment cycle.
Buying Guide: Key Purchase Considerations And Comparisons
- Active ingredient and target diseases: Different products feature varying active ingredients and disease spectrums. Check the label to ensure the product addresses the specific fungi you’re most concerned about, such as brown patch, powdery mildew, or Phytophthora.
- Plant compatibility and safety: Consider whether the product is suitable for turf, ornamentals, roses, or edible crops. Some formulations emphasize turf and landscape use, while others are optimized for flowering plants.
- Watering and application method: Liquid concentrates require mixing with water, whereas ready-to-spray formulas are ready to use. Ensure you have the right sprayer setup and follow label instructions for coverage and frequency.
- Coverage and dosage: Larger volumes (like 32 oz) are better for bigger lawns or multi-plant setups. Pay attention to dilution rates and application intervals to prevent resistance and ensure effective protection.
- Curative vs. preventive action: Some products offer both curative and preventive protection, while others are more preventive in nature. If disease pressure is high, a product with both properties can be advantageous.
- Resistance management: Rotate products with different active ingredients to minimize pathogen resistance. This is particularly important for long-term disease control in lawns and gardens.
- Environmental and safety considerations: Look for formulations that minimize residue and are safe for people, pets, and pollinators when used as directed. Citric-acid-based or more environmentally friendly options may suit households with children and pets.
- Label compliance: Always read and follow the label for rates, re-application intervals, and plant-specific warnings. Labels provide the most authoritative guidance for safe and effective use.
- Cost-to-coverage: Compare price and the area covered per bottle to evaluate value. A higher upfront cost can be more economical if the product covers larger areas and reduces disease recurrences.
- Brand support and availability: Reputable brands with clear label information and readily available customer support can help with troubleshooting and proper usage over seasons.